Opportunity Information: Apply for SFOP0008390
The Global Biological Threat Reduction and Border Security grant opportunity (SFOP0008390) is a U.S. Department of State program run through the Bureau of Oceans and International Environmental and Scientific Affairs, focused on reducing the risk that high consequence pathogens could cause harm through accidental release, natural outbreak, or deliberate misuse. The central idea is to help foreign partners build stronger, more coordinated systems across public health, animal health, law enforcement, and border security so they can prevent biological incidents, spot them earlier when they occur, and respond in a way that limits spread and impact. The program is positioned squarely in the biological nonproliferation space, meaning it is not only about routine disease control but also about reducing opportunities for actors to obtain, move, or weaponize dangerous biological materials.
A major emphasis of the opportunity is improving pathogen detection capacity in a way that is both effective and secure. That includes strengthening laboratory-level capabilities to identify high consequence pathogens safely, as well as improving network-level detection systems so information can move quickly between labs, clinics, veterinary services, and relevant government authorities. The intent is to reduce blind spots where outbreaks can grow undetected and to ensure that diagnostic and reporting pipelines are resilient enough to function during high-pressure incidents. Just as importantly, the program highlights the need for safe and secure operations, suggesting that detection upgrades are expected to go hand-in-hand with controls that reduce theft, diversion, mishandling, and other biosafety and biosecurity failures.
Another core component is upgrading biosafety and biosecurity infrastructure and practices in laboratories and medical facilities that might encounter or work with high consequence pathogens. In practical terms, this can involve strengthening facility procedures, training, and oversight so that people, pathogens, and sensitive information are managed responsibly. It also points to improving the physical and operational safeguards that keep dangerous agents from being accessed by unauthorized individuals and that reduce the chance of lab-associated infections or accidental releases. The program framing makes clear that these improvements are meant to lower both public health risks and proliferation risks, recognizing that weak laboratory security and weak safety cultures can create openings for harm even when the original intent of the facility is legitimate research or diagnostics.
The opportunity also stresses multisectoral coordination, treating effective response as something that must span human health, animal health, law enforcement, and border and customs authorities. This reflects the reality that many significant pathogens are zoonotic or can move between animals and humans, and that deliberate biological events can look like natural outbreaks at the start. By promoting coordination, the program aims to ensure that agencies share information, align protocols, and act quickly when warning signs appear, whether those warning signs come from hospitals, veterinary reporting, border seizures, or intelligence and investigative leads. Strengthening these linkages is positioned as essential for efficient prevention, detection, and response, especially in complex incidents where public health actions and security actions must be synchronized.
Geographically and strategically, ISN/NDF indicates it will prioritize countries and regions where three risk factors overlap: a high burden of endemic high consequence pathogens, evidence of interest or capability by state or nonstate actors to use biological agents, and the presence of biological infrastructure that could be attractive to malicious actors. This suggests the funding is aimed at higher-risk environments where improvements in laboratory security, detection networks, and cross-agency collaboration could meaningfully reduce the chances of dangerous pathogens being mishandled, stolen, smuggled, or intentionally released. The targeting language also signals that applicants should be prepared to show how proposed activities align with these risk-based priorities and why the selected partner locations matter from a threat-reduction and border-security perspective.
In terms of administrative details, this is a discretionary grant opportunity with an award ceiling of $8,500,000 and an expectation of about four awards. The CFDA number listed is 19.224. The eligible applicant category specified is nonprofits that do not have a 501(c)(3) status with the IRS (other than institutions of higher education), which narrows who can apply directly and implies that some organizations may need to consider partnership structures if they do not fit the eligibility definition. The opportunity was created on September 22, 2021, with an original closing date of November 22, 2021. Overall, the grant is structured to fund projects that measurably reduce biological risk by strengthening secure detection, modernizing biosafety and biosecurity practices, and building durable coordination among health and security actors at points where outbreaks and cross-border movement of pathogens can be stopped or contained early.Apply for SFOP0008390
- The Department of State, Bureau of Oceans - Int. Environmental - Scientific in the other (see text field entitled explanation of other category of funding activity for clarification) sector is offering a public funding opportunity titled "Global Biological Threat Reduction and Border Security" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 19.224.
- This funding opportunity was created on Sep 22, 2021.
- Applicants must submit their applications by Nov 22, 2021. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $8,500,000.00 in funding.
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
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Applicants also applied for:
Applicants who have applied for this opportunity (SFOP0008390) also looked into and applied for these:
| Funding Opportunity |
|---|
| Global Biological Threat Reduction and Border Security Apply for SFOP0008399 Funding Number: SFOP0008399 Agency: Department of State, Bureau of International Security-Nonproliferation Category: Other (see text field entitled Explanation of Other Category of Funding Activity for clarification) Funding Amount: $8,500,000 |
| 21.PMWRA.22November2021.Unsolicited.RFI Apply for SFOP0008400 Funding Number: SFOP0008400 Agency: Department of State, Bureau of Political-Military Affairs - WRA Category: Other (see text field entitled Explanation of Other Category of Funding Activity for clarification) Funding Amount: Case Dependent |
| FY 2022 Gandhi-King Scholarly Exchange Initiative Apply for SFOP0008403 Funding Number: SFOP0008403 Agency: Department of State, Bureau Of Educational and Cultural Affairs Category: Other (see text field entitled Explanation of Other Category of Funding Activity for clarification) Funding Amount: $400,000 |
| FY 2022 Community College Initiative Program Apply for SFOP0008402 Funding Number: SFOP0008402 Agency: Department of State, Bureau Of Educational and Cultural Affairs Category: Other (see text field entitled Explanation of Other Category of Funding Activity for clarification) Funding Amount: $5,275,000 |
| Environmental Injustice and the Impact of the Increased Frequency of Extreme Weather Events on People with Disabilities Apply for NCD 22 01 Funding Number: NCD 22 01 Agency: National Council on Disability Category: Other (see text field entitled Explanation of Other Category of Funding Activity for clarification) Funding Amount: $185,000 |
| 2022 Alaska Native Organization Co-Management Funding Program Apply for NOAA NMFS AK 2022 2006961 Funding Number: NOAA NMFS AK 2022 2006961 Agency: Department of Commerce Category: Other (see text field entitled Explanation of Other Category of Funding Activity for clarification) Funding Amount: $800,000 |
| U.S. Embassy Bridgetown PAS Annual Program Statement Apply for PAS BGI FY22 01 Funding Number: PAS BGI FY22 01 Agency: Department of State, U.S. Mission to Barbados Category: Other (see text field entitled Explanation of Other Category of Funding Activity for clarification) Funding Amount: $24,000 |
| Increased compliance with Mexican labor law and international labor standards by the tomato and chile pepper sectors in Mexico Apply for FOA ILAB 21 17 Funding Number: FOA ILAB 21 17 Agency: Department of Labor, Bureau of International Labor Affairs Category: Other (see text field entitled Explanation of Other Category of Funding Activity for clarification) Funding Amount: $5,000,000 |
| FY 2022 Future Leaders Exchange (FLEX) Program: Student Placement and Monitoring Apply for SFOP0008411 Funding Number: SFOP0008411 Agency: Department of State, Bureau Of Educational and Cultural Affairs Category: Other (see text field entitled Explanation of Other Category of Funding Activity for clarification) Funding Amount: $10,365,000 |
| DRL FY21 IRF NEA Combatting Antisemitism Online Apply for SFOP0008377 Funding Number: SFOP0008377 Agency: Department of State, Bureau of Democracy Human Rights and Labor Category: Other (see text field entitled Explanation of Other Category of Funding Activity for clarification) Funding Amount: $1,000,000 |
| Ambassador’s Special Self-Help Program 2022 Apply for DOS KAM AMBSSH FY21 Funding Number: DOS KAM AMBSSH FY21 Agency: Department of State, U.S. Mission to Uganda Category: Other (see text field entitled Explanation of Other Category of Funding Activity for clarification) Funding Amount: $10,000 |
| Incentivizing Oral Healthcare Providers to Treat Patients with Intellectual & Developmental Disabilities Apply for NCD 22 02 Funding Number: NCD 22 02 Agency: National Council on Disability Category: Other (see text field entitled Explanation of Other Category of Funding Activity for clarification) Funding Amount: $100,000 |
| To Assess a Long-Standing Administrative Exclusion under Federal Employment Tax Law for People with Disabilities in Congregate Work Settings for Federal Employment Tax Purposes Apply for NCD 22 03 Funding Number: NCD 22 03 Agency: National Council on Disability Category: Other (see text field entitled Explanation of Other Category of Funding Activity for clarification) Funding Amount: $100,000 |
| Fiscal Year 2021 Presidential Residence Protection Assistance Grant (PRPA) Apply for DHS 21 GPD 134 00 01 Funding Number: DHS 21 GPD 134 00 01 Agency: Department of Homeland Security, Department of Homeland Security - FEMA Category: Other (see text field entitled Explanation of Other Category of Funding Activity for clarification) Funding Amount: Case Dependent |
| U.S. Embassy Belgrade - Ambassadors Fund for Cultural Protection Apply for SRB10022FO 01 Funding Number: SRB10022FO 01 Agency: Department of State, U.S. Mission to Serbia Category: Other (see text field entitled Explanation of Other Category of Funding Activity for clarification) Funding Amount: $500,000 |
| U.S. Embassy La Paz - PAS Annual Program Statement Apply for PAS LAPAZ FY22 01 Funding Number: PAS LAPAZ FY22 01 Agency: Department of State, U.S. Mission to Bolivia Category: Other (see text field entitled Explanation of Other Category of Funding Activity for clarification) Funding Amount: $40,000 |
| Enhancing Transparency and Accountability in Uzbekistan’s Cotton Industry Apply for NOI ILAB 21 04 Funding Number: NOI ILAB 21 04 Agency: Department of Labor, Bureau of International Labor Affairs Category: Other (see text field entitled Explanation of Other Category of Funding Activity for clarification) Funding Amount: $5,000,000 |
| Border Management Study – U.S.-Mexico Border Apply for INL22GR0001 WHPMEX BORDMGMT 10202021 Funding Number: INL22GR0001 WHPMEX BORDMGMT 10202021 Agency: Department of State, Bureau of International Narcotics-Law Enforcement Category: Other (see text field entitled Explanation of Other Category of Funding Activity for clarification) Funding Amount: $250,000 |
| FY22 Counter Russia Malign Influence Apply for SFOP0008418 Funding Number: SFOP0008418 Agency: Department of State, Bureau of International Security-Nonproliferation Category: Other (see text field entitled Explanation of Other Category of Funding Activity for clarification) Funding Amount: $500,000 |
| Countering Russian Chemical and Biological Threats Apply for SFOP0008421 Funding Number: SFOP0008421 Agency: Department of State, Bureau of International Security-Nonproliferation Category: Other (see text field entitled Explanation of Other Category of Funding Activity for clarification) Funding Amount: $500,000 |
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