Opportunity Information: Apply for PAR 24 133
The Small Business Transition Grant for New Entrepreneurs (R41/R42, Clinical Trial Not Allowed), listed as NIH funding opportunity PAR-24-133, is a discretionary NIH grant designed to help researchers who are new to entrepreneurship make a structured transition into the small business world while still advancing real research and development. The central idea is to support a small business concern (SBC) that hires or retains a scientist or health professional to serve as the Program Director/Principal Investigator (PD/PI), then deliberately builds that persons entrepreneurial abilities alongside the technical work. In other words, the award is not just about funding a promising technology project; it is also about shaping the PD/PI into a capable entrepreneurial leader who can guide an early-stage product or technology toward practical health impact.
A defining feature of this NOFO is its dual emphasis on research progress and professional development. NIH expects the funded effort to include substantial entrepreneurial training, mentoring, and career development for the PD/PI, rather than leaving business skill-building to chance. The ideal PD/PI is someone with strong technical depth, such as experience in scientific research, technology development, or healthcare delivery, but who has limited experience leading independent R and D projects or operating in an entrepreneurial environment. The grant is meant to create a supported runway where that individual can learn how to think like a founder or product-focused leader while still operating within a rigorous NIH-supported R and D framework.
From a project standpoint, the work should focus on developing promising technologies or products that align with NIHs mission to improve health and save lives. Although the detailed scientific scope can vary widely across NIH institutes and centers, the underlying expectation is that the R and D will be purpose-driven and translational in nature, aimed at advancing solutions with clear potential to benefit patients, public health, or healthcare systems. The "Clinical Trial Not Allowed" designation is important: applications proposing clinical trials are not permitted under this opportunity, so the supported activities generally remain in preclinical development, tool development, platform development, or other non-clinical trial stages of translational research.
Eligibility is focused on U.S. small businesses. Foreign organizations (non-U.S. entities) are not eligible to apply, and non-domestic components of U.S. organizations are also not eligible. That said, foreign components, as NIH defines them in the NIH Grants Policy Statement, may be allowed in some circumstances, which typically means certain discrete parts of the work could be performed abroad if justified and compliant with NIH rules, but the applicant organization itself must be an eligible U.S. small business. This structure keeps the primary investment and entrepreneurial development anchored within the U.S. small business ecosystem while still leaving limited room for specialized international collaboration when appropriate.
Administratively, this opportunity is offered as a grant within the broad NIH mission space and is tied to multiple CFDA listings (including 93.113, 93.121, 93.172, 93.173, 93.213, 93.233, 93.273, 93.279, 93.350, 93.361, 93.837, 93.838, 93.839, 93.840, 93.846, 93.859, 93.865, 93.866, 93.867, and 93.879), reflecting that different NIH institutes and programs may participate depending on the topic area. The original closing date shown is 2027-04-05, and the opportunity was created on 2024-04-25. While the source data does not list an award ceiling or expected number of awards, applicants should typically expect NIH small business funding details, budgets, and project periods to be governed by the specific rules of the R41/R42 mechanism and institute-specific guidance referenced in the full NOFO.
Overall, this NOFO is best understood as a transition-and-training focused small business R and D award: it supports a small business to move a health-relevant technology forward while intentionally developing a newer entrepreneur into an effective PD/PI who can lead innovation in a commercial setting. The emphasis on mentoring and career development is not a side benefit; it is one of the main reasons the program exists, and applicants should be prepared to describe both a credible technical plan and a credible plan for entrepreneurial growth.Apply for PAR 24 133
- The National Institutes of Health in the education, environment, health, income security and social services sector is offering a public funding opportunity titled "Small Business Transition Grant for New Entrepreneurs (R41/R42 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.172, 93.173, 93.213, 93.233, 93.273, 93.279, 93.350, 93.361, 93.837, 93.838, 93.839, 93.840, 93.846, 93.859, 93.865, 93.866, 93.867, 93.879.
- This funding opportunity was created on 2024-04-25.
- Applicants must submit their applications by 2027-04-05.
- Eligible applicants include: Small businesses.
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Applicants also applied for:
Applicants who have applied for this opportunity (PAR 24 133) also looked into and applied for these:
| Funding Opportunity |
|---|
| PHS 2024-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Required) Apply for PA 24 248 Funding Number: PA 24 248 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) Postdoctoral Career Transition Award to Promote Diversity (K99/R00 - Independent Basic Experimental Studies with Humans Required (BESH)) Apply for PAR 24 227 Funding Number: PAR 24 227 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Human Brain Single-cell Genomics Explorer (U24 - Clinical Trial Not Allowed) Apply for RFA NS 24 038 Funding Number: RFA NS 24 038 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: $1,000,000 |
| Environmental Health Disparities Centers (P50) Clinical Trial Optional Apply for RFA MD 24 010 Funding Number: RFA MD 24 010 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Dissemination and Implementation Research in Health (R03 Clinical Trial Not Allowed) Apply for PAR 25 233 Funding Number: PAR 25 233 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Dissemination and Implementation Research in Health (R21 Clinical Trial Optional) Apply for PAR 25 143 Funding Number: PAR 25 143 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32) Apply for PA 25 168 Funding Number: PA 25 168 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Not Allowed) Apply for PAR 25 298 Funding Number: PAR 25 298 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: $375,000 |
| NIH Small Research Grant Program (Parent R03 Clinical Trial Not Allowed) Apply for PA 25 302 Funding Number: PA 25 302 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: $50,000 |
| NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed) Apply for PA 25 304 Funding Number: PA 25 304 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Required) Apply for PA 25 306 Funding Number: PA 25 306 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ethical, Legal and Social Implications (ELSI) Research (R01 Clinical Trial Optional) Apply for PAR 25 371 Funding Number: PAR 25 371 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ethical, Legal and Social Implications (ELSI) Exploratory/Developmental Research Grant (R21 Clinical Trial Optional) Apply for PAR 25 369 Funding Number: PAR 25 369 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ethical, Legal and Social Implications (ELSI) Small Research Grant (R03 Clinical Trial Optional) Apply for PAR 25 370 Funding Number: PAR 25 370 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: $50,000 |
| Intervention Research to Improve Native American Health (R34 Clinical Trial Optional) Apply for PAR 25 378 Funding Number: PAR 25 378 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Basic Experimental Studies with Human Required) Apply for PAR 25 323 Funding Number: PAR 25 323 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
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