Opportunity Information: Apply for PAR 22 133
The NIDA Research Center of Excellence Grant Program (P50 Clinical Trial Optional), Funding Opportunity Number PAR-22-133, is a National Institutes of Health discretionary grant designed to build and sustain high-impact research centers focused on drug abuse and addiction across any area within NIDA's mission. The program is structured around the idea that a P50 Center should do more than fund a collection of related projects; it should function as an integrated, multidisciplinary hub where teams collaborate across disciplines and methods to produce work that is thematically connected, synergistic, and capable of shifting the direction of the field. The "clinical trial optional" framing indicates that a Center may propose clinical trials if they fit the scientific aims, but clinical trials are not required for eligibility.
A central expectation of this opportunity is scientific ambition. NIDA signals that incremental or purely confirmatory work should not be the main focus. Instead, proposed Centers should pursue new, creative directions and generate innovative science that can realistically transform knowledge in the areas being studied. In practice, that means reviewers will likely be looking for a coherent vision, clear scientific leadership, and research projects that mutually reinforce one another through shared frameworks, common resources, and coordinated strategies, rather than operating as separate, loosely related studies.
Beyond producing publishable findings, the Center is also expected to operate as a national resource for the broader community. This includes educational and outreach activities that connect the Center's expertise to drug abuse research communities, educational organizations, the general public, and policy makers working in or affected by NIDA-relevant research areas. The FOA emphasizes broad dissemination and responsible sharing, with a goal of creating Centers that actively share findings, data, and research resources as appropriate so other investigators can use them, build upon them, and accelerate progress in the field. In other words, the Center is meant to have influence outside its home institution by supporting knowledge transfer, capacity-building, and field-wide advancement.
Workforce development is another explicit goal. The P50 Center of Excellence mechanism is expected to foster career development and mentoring for new investigators, giving them meaningful roles within Center projects rather than peripheral participation. This focus reflects a long-term investment strategy: NIDA is not only funding the science produced during the award period, but also trying to strengthen the pipeline of emerging researchers who will lead future advances in drug abuse and addiction research.
In terms of eligibility, the FOA allows applications from a wide range of U.S.-based organizations and governmental units. Eligible applicants include state, county, city or township governments; special district governments; independent school districts; public housing authorities/Indian housing authorities; federally recognized Native American tribal governments; and Native American tribal organizations other than federally recognized tribal governments. It also includes public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with and without 501(c)(3) status (other than institutions of higher education), for-profit organizations other than small businesses, small businesses, and other eligible entities. The announcement also highlights additional eligible applicant types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions.
Restrictions on foreign involvement are clear. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply, non-domestic components of U.S. organizations are not eligible to apply, and foreign components as defined by the NIH Grants Policy Statement are not allowed. This effectively limits the applicant organization and its components to domestic operations and disallows formal foreign components within the proposed Center structure.
The opportunity is categorized under Education and Health, with CFDA number 93.279, and is offered as a grant mechanism under NIH. The original closing date listed for the opportunity is January 12, 2023, and the FOA creation date is March 14, 2022. The source information does not specify an award ceiling or the expected number of awards in the fields provided, so applicants would typically need to consult the full FOA and NIH budget guidance for the P50 mechanism to understand allowable costs, project period expectations, and any institute-specific budget considerations.
Taken together, PAR-22-133 is aimed at supporting Centers that can act as engines of innovation in addiction science: tightly integrated research programs that are multidisciplinary by design, ambitious in scope, committed to mentoring new investigators, and structured to share knowledge and resources broadly so the Center's impact extends well beyond the funded institution.Apply for PAR 22 133
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "NIDA Research Center of Excellence Grant Program (P50 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279.
- This funding opportunity was created on 2022-03-14.
- Applicants must submit their applications by 2023-01-12. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the NIDA Research Center of Excellence Grant Program (P50 Clinical Trial Optional)?
It is a National Institutes of Health (NIH) discretionary grant program funded by the National Institute on Drug Abuse (NIDA) to build and sustain high-impact research centers focused on drug abuse and addiction across any area within NIDA's mission. The opportunity uses the P50 Center mechanism and is intended to support integrated, multidisciplinary research hubs rather than a loose collection of separate projects.
What is the Funding Opportunity Number for this program?
The Funding Opportunity Number (FOA) is PAR-22-133.
What does "P50" mean in this opportunity?
P50 refers to an NIH Center grant mechanism. In this program, a P50 Center is expected to function as an integrated, thematically connected research center where projects and teams reinforce one another through shared frameworks, common resources, and coordinated strategies.
What does "Clinical Trial Optional" mean?
"Clinical Trial Optional" means a proposed Center may include clinical trials if they are appropriate for the scientific aims, but clinical trials are not required to be eligible or competitive under this FOA.
What kinds of research topics are supported?
The Center can focus on any area within NIDA's mission related to drug abuse and addiction. The key expectation is that the overall program is thematically coherent, multidisciplinary, and designed to generate synergistic advances rather than disconnected findings.
What is NIDA expecting from a P50 Center beyond funding multiple projects?
NIDA expects a P50 Center to operate as an integrated, multidisciplinary hub where researchers collaborate across disciplines and methods. The Center's work should be coordinated, mutually reinforcing, and capable of shifting the direction of the field, rather than operating as a set of loosely related studies.
How important is innovation and scientific ambition in this program?
Scientific ambition is a central expectation. NIDA signals that incremental or purely confirmatory work should not be the main focus. Proposed Centers are expected to pursue new, creative directions and generate innovative science that can realistically transform understanding in the chosen areas.
What will reviewers likely look for in a competitive application (based on the description provided)?
Based on the provided description, reviewers will likely value a coherent overall vision, clear scientific leadership, and research projects that are thematically connected and synergistic through shared frameworks, resources, and coordinated strategies.
Is the Center expected to serve people outside the applicant institution?
Yes. The Center is expected to operate as a national resource for the broader community through educational and outreach activities that connect the Center's expertise to drug abuse research communities, educational organizations, the general public, and policy makers in NIDA-relevant areas.
What kinds of outreach or dissemination activities are expected?
The FOA emphasizes broad dissemination and responsible sharing. Centers are expected to share findings, data, and research resources as appropriate so other investigators can use them, build upon them, and accelerate progress in the field.
Does this program include a workforce development or mentoring expectation?
Yes. Workforce development is an explicit goal. The P50 Center is expected to foster career development and mentoring for new investigators, including giving them meaningful roles within Center projects rather than peripheral participation.
Who is eligible to apply?
The FOA allows applications from a wide range of U.S.-based organizations and governmental units, including state, county, city, or township governments; special district governments; independent school districts; public housing authorities/Indian housing authorities; federally recognized Native American tribal governments; and Native American tribal organizations other than federally recognized tribal governments. Eligible applicants also include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with and without 501(c)(3) status (other than institutions of higher education), for-profit organizations other than small businesses, small businesses, and other eligible entities.
Are minority-serving institutions specifically mentioned as eligible?
Yes. The announcement highlights additional eligible applicant types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Are faith-based or community-based organizations eligible?
Yes. The eligibility description explicitly includes faith-based or community-based organizations among eligible applicant types.
Are federal agencies eligible to apply?
Yes. The announcement includes eligible federal agencies as eligible applicants.
Are U.S. territories or possessions eligible?
Yes. The opportunity description includes U.S. territories or possessions among eligible applicant types.
Can a non-U.S. (foreign) organization apply?
No. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply.
Can the non-U.S. component of a U.S. organization apply?
No. Non-domestic components of U.S. organizations are not eligible to apply.
Are foreign components allowed within an otherwise U.S.-based application?
No. Foreign components, as defined by the NIH Grants Policy Statement, are not allowed under this opportunity.
What is the CFDA number associated with this opportunity?
The CFDA number listed is 93.279.
What category is this opportunity listed under?
The opportunity is categorized under Education and Health.
What is the original closing date listed for this opportunity?
The original closing date listed is January 12, 2023.
What is the FOA creation date?
The FOA creation date is March 14, 2022.
Is there an award ceiling listed in the provided information?
No. The source information provided does not specify an award ceiling.
Does the provided information state how many awards are expected?
No. The fields provided do not specify the expected number of awards.
Where should applicants look for budget limits, allowable costs, and project period expectations?
The provided description indicates applicants would typically need to consult the full FOA and NIH budget guidance for the P50 mechanism to understand allowable costs, project period expectations, and any institute-specific budget considerations.
What is the overall purpose of PAR-22-133 in practical terms?
PAR-22-133 is intended to support Centers that act as engines of innovation in addiction science: tightly integrated, multidisciplinary programs that are ambitious in scope, committed to mentoring new investigators, and structured to share knowledge and resources broadly so the Center's impact extends beyond the funded institution.
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