Opportunity Information: Apply for PAR 23 055
The Co-infection and Cancer (R01 Clinical Trial Not Allowed) opportunity (PAR-23-055) is a National Institutes of Health (NIH) discretionary grant program that supports research aimed at clarifying how co-infections contribute to cancers that are caused or influenced by infectious agents. The central goal is to strengthen both mechanistic and epidemiologic understanding of infection-related cancers by focusing specifically on the etiologic, or causal, roles that co-infections may play in cancer initiation, progression, and related disease pathways. In this context, co-infection is defined broadly as infection by two or more agents that may occur at the same time or in sequence, and it explicitly includes acute or chronic infections caused by viruses, bacteria, parasites, and other microorganisms. A key emphasis is on generating knowledge that can open up new and practical avenues for cancer prevention and treatment, particularly where co-infection biology creates intervention points that would not be apparent when studying a single pathogen in isolation.
A notable priority for this initiative is the study of co-infections other than those involving human immunodeficiency virus (HIV). While HIV is widely recognized for its relationship to several cancers and for its interaction with other infections, this specific funding announcement indicates that preference will be given to non-HIV co-infection combinations. The program also signals a strong interest in projects that focus on understudied populations, which can include communities with disproportionate burdens of infection-associated cancers, limited representation in research cohorts, unique exposure patterns, or barriers to prevention and care. By steering attention toward these populations, the initiative aims to fill important knowledge gaps that may be limiting equitable progress in cancer control and outcomes.
The award mechanism is an R01 research project grant, which typically supports hypothesis-driven, investigator-initiated research with clearly defined aims and a multi-year plan. The announcement specifies "Clinical Trial Not Allowed," meaning applicants should propose studies that do not meet the NIH definition of a clinical trial. In practice, this generally points applicants toward observational epidemiology, translational or preclinical research, laboratory-based mechanistic studies, analyses of existing biospecimens or datasets, development of models to understand co-infection dynamics, and other human-subjects research that is not interventional. Projects are expected to deepen understanding of causal pathways, interactions between pathogens, host responses, immune modulation, inflammation, microbiome-related effects, or other biological and population-level mechanisms by which multiple infectious exposures may jointly shape cancer risk or tumor behavior.
Eligibility for this program is broad and includes many standard applicant types such as state, county, city, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and other entities. The announcement additionally highlights a wide range of "Other Eligible Applicants," reinforcing that the NIH is open to applications from Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and foreign (non-U.S.) organizations. This breadth of eligibility supports multidisciplinary and cross-sector partnerships, including research that may require international collaboration when certain infection exposures or cancer burdens are concentrated outside the United States.
From the posted source data, the opportunity falls under CFDA number 93.393 and is categorized within Education and Health funding activity areas. The original closing date listed is 2025-11-05, and the opportunity was created on 2022-12-14. The notice does not provide an award ceiling or expected number of awards in the excerpt, so prospective applicants would typically look to the full funding announcement and NIH institute participation details to understand budget expectations, project period norms, and institute-specific interests. Overall, the program is designed to move the field beyond single-pathogen models by supporting rigorous research on how multiple infections interact with each other and the host to influence cancer risk and outcomes, with particular attention to prevention and treatment opportunities and to populations that have historically been overlooked in infection-related cancer research.Apply for PAR 23 055
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Co-infection and Cancer (R01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393.
- This funding opportunity was created on 2022-12-14.
- Applicants must submit their applications by 2025-11-05. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Applicants also applied for:
Applicants who have applied for this opportunity (PAR 23 055) also looked into and applied for these:
| Funding Opportunity |
|---|
| Co-infection and Cancer (R21 Clinical Trial Not Allowed) Apply for PAR 23 056 Funding Number: PAR 23 056 Agency: National Institutes of Health Category: Education, Health Funding Amount: $275,000 |
| Mechanisms and Targets at the Intersection of HIV and Substance Use (R21 Clinical Trials Not Allowed) Apply for RFA DA 24 014 Funding Number: RFA DA 24 014 Agency: National Institutes of Health Category: Education, Health Funding Amount: $275,000 |
| Mechanisms and Targets at the Intersection of HIV and Substance Use (R01 Clinical Trials Not Allowed) Apply for RFA DA 24 013 Funding Number: RFA DA 24 013 Agency: National Institutes of Health Category: Education, Health Funding Amount: $400,000 |
| Substance Use Prevention Effectiveness Research Among Youth and Families in the Child Welfare System (R61/R33 Clinical Trial Required) Apply for RFA DA 24 011 Funding Number: RFA DA 24 011 Agency: National Institutes of Health Category: Education, Health Funding Amount: $600,000 |
| Substance Use Prevention Effectiveness Research Among Youth and Families in the Child Welfare System (R01 Clinical Trial Required) Apply for RFA DA 24 012 Funding Number: RFA DA 24 012 Agency: National Institutes of Health Category: Education, Health Funding Amount: $600,000 |
| Development of Innovative Informatics Methods and Algorithms for Cancer Research and Management (R21 Clinical Trial Optional) Apply for RFA CA 23 014 Funding Number: RFA CA 23 014 Agency: National Institutes of Health Category: Education, Health Funding Amount: $275,000 |
| Advanced Development of Informatics Technologies for Cancer Research and Management (U24 Clinical Trial Optional) Apply for RFA CA 23 016 Funding Number: RFA CA 23 016 Agency: National Institutes of Health Category: Education, Health Funding Amount: $600,000 |
| Early-Stage Development of Informatics Technologies for Cancer Research and Management (U01 Clinical Trial Optional) Apply for RFA CA 23 015 Funding Number: RFA CA 23 015 Agency: National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
| Sustained Support for Informatics Technologies for Cancer Research and Management (U24 Clinical Trial Optional) Apply for RFA CA 23 017 Funding Number: RFA CA 23 017 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Translational Centers for Microphysiological Systems (TraCe MPS) (U2C Clinical Trials Not Allowed) Apply for RFA TR 23 001 Funding Number: RFA TR 23 001 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NIDA Core "Center of Excellence" Grant Program (P30 Clinical Trial Optional) Apply for PAR 23 049 Funding Number: PAR 23 049 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Revision Applications for Validation of Biomarker Assays Developed Through NIH-Supported Research Grants (R01 Clinical Trial Not Allowed) Apply for PAR 23 088 Funding Number: PAR 23 088 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| NIDA Program Project Grant Applications (P01 Clinical Trial Optional) Apply for PAR 23 064 Funding Number: PAR 23 064 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NIDA Research Center of Excellence Grant Program (P50 Clinical Trial Optional) Apply for PAR 23 076 Funding Number: PAR 23 076 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Career Enhancement Award to Advance Research on Firearm Injury and Mortality Prevention (K18 Independent Clinical Trial Required) Apply for PAR 23 107 Funding Number: PAR 23 107 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Career Enhancement Award to Advance Research on Firearm Injury and Mortality Prevention (K18 Independent Clinical Trial Not Allowed) Apply for PAR 23 108 Funding Number: PAR 23 108 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Accelerating the Pace of Drug Abuse Research Using Existing Data (R21 Clinical Trial Optional) Apply for RFA DA 24 037 Funding Number: RFA DA 24 037 Agency: National Institutes of Health Category: Education, Health Funding Amount: $275,000 |
| Education Activities for Responsible Analyses of Complex, Large-Scale Data (R25- Clinical Trial Not Allowed) Apply for RFA DA 24 027 Funding Number: RFA DA 24 027 Agency: National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
| Leveraging Big Data Science to Elucidate the Mechanisms of HIV Activity and Interaction with Substance Use Disorder (R21 Clinical Trials Not Allowed) Apply for RFA DA 24 009 Funding Number: RFA DA 24 009 Agency: National Institutes of Health Category: Education, Health Funding Amount: $275,000 |
| Leveraging Big Data Science to Elucidate the Mechanisms of HIV Activity and Interaction with Substance Use Disorder (R01 Clinical Trials Not Allowed) Apply for RFA DA 24 008 Funding Number: RFA DA 24 008 Agency: National Institutes of Health Category: Education, Health Funding Amount: $350,000 |
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